Student Researcher Spotlight
DOI:
https://doi.org/10.29173/eureka28836Abstract
Aryan and Taylor’s image, titled Mouse Radial Nerve in Cross-section, is featured on the back cover of the issue. The peripheral nervous system is composed of different axonal subpopulations that are responsible for carrying out information on essential processes such as pain, muscle contraction, and mechanoreception from the periphery to the brain. In this triple fluorescent image of the mouse Radial nerve in cross-section, each color represents a different axonal subpopulation. The red channel labels CHAT (Choline Acetyltransferase)+ motor axons which allow for skeletal muscle contraction in response to stimuli. The green channel labels CGRP (Calcitonin Gene Related Peptide)+ nociceptive (pain) axons which are responsible for a sustained release of inflammatory factors in response to tissue injury. The teal channel (Neurofilament 200) labels all the remaining proprioceptive and mechanoreceptive axonal subpopulations in the nerve. This image is the result of an immunohistochemistry protocol where a specific antibody with a fluorescent tag binds to the desired protein on the axon. This image, along with various images of different upper and lower limb nerves, allow us to quantify these subpopulations which may be critical for the development of future pain models and surgical interventions.
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