Organic Glues or Fibrin Glues from Pooled Plasma: Efficacy, Safety and Potential as Scaffold Delivery Systems

Authors

  • Clémence Tabélé Service de la pharmacie à usage intérieure de l'hôpital de la Conception, Marseille, France
  • marc montana Laboratoire de Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Universités d’Aix-Marseille I, II et III, UMR-CNRS 6264, , Marseille, France
  • christophe curti Laboratoire de Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Universités d’Aix-Marseille I, II et III, UMR-CNRS 6264, Laboratoire Chimie Provence, Marseille, France Assistance Publique - Hôpitaux de Marseille (AP-HM), Service Central de la Qualité et de l’Information Pharmaceutiques, Marseille, France
  • thierry terme Laboratoire de Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Universités d’Aix-Marseille I, II et III, UMR-CNRS 6264, Laboratoire Chimie Provence, Marseille, France
  • pascal rathelot Laboratoire de Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Universités d’Aix-Marseille I, II et III, UMR-CNRS 6264, Laboratoire Chimie Provence, Marseille, France Assistance Publique - Hôpitaux de Marseille (AP-HM), Service Central de la Qualité et de l’Information Pharmaceutiques, Marseille, France
  • sophie gensollen Service de la pharmacie à usage intérieure de l'hôpital de la Conception, Marseille, France
  • patrice vanelle Laboratoire de Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Universités d’Aix-Marseille I, II et III, UMR-CNRS 6264, Laboratoire Chimie Provence, Marseille, France Assistance Publique - Hôpitaux de Marseille (AP-HM), Service Central de la Qualité et de l’Information Pharmaceutiques, Marseille, France

DOI:

https://doi.org/10.18433/J39K5H

Abstract

Since 1976, fibrin glues have been attracting medical interest, spreading from their initial use as a hemostatic agent in cardiovascular surgery to other fields of surgery. Studies have compared the efficacy of fibrin glues vs sutures in surgery. However, few comparisons have been made of the efficacy and safety of the different fibrin glues commercially available. Recently, fibrin glues have been tested as a scaffold delivery system for various substances inside the body (drugs, growth factors, stem cells). The infectious risk (viruses, new germs) of this blood-derived product was also studied in assays on viral inactivation methods. The development of autologous fibrin glues offers a solution to the problem of infectious risk. This review examines the current state of knowledge on the efficacy, safety and future potential of fibrin glues. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

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Published

2012-01-20

How to Cite

Tabélé, C., montana, marc, curti, christophe, terme, thierry, rathelot, pascal, gensollen, sophie, & vanelle, patrice. (2012). Organic Glues or Fibrin Glues from Pooled Plasma: Efficacy, Safety and Potential as Scaffold Delivery Systems. Journal of Pharmacy & Pharmaceutical Sciences, 15(1), 124–140. https://doi.org/10.18433/J39K5H

Issue

Vol. 15 No. 1 (2012)

Section

Review Articles

License

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