Potential Renoprotective Effects of Silymarin Against Nephrotoxic Drugs: A Review of Literature

Foroud Shahbazi, Simin Dashti-Khavidaki, Hossein Khalili, Mahboob Lessan-Pezeshki


Drug-induced nephrotoxicity (DIN) accounts for up to sixty percent of hospital acquired acute kidney injury. Several efforts have been made to reduce drug-induced renal damage; however, DIN remains a matter of concern, with substantial impact on patients and the health system. Silymarin is a drug that has been used for many years in alternate and modern medicine for treating hepatic diseases. Its antioxidant, anti-inflammatory and anti-apoptotic effects make it an interesting herbal medicine, and these properties have implicated this compound as a potential renoprotective agent. Based on the findings from animal studies, this review concluded that silymarin might exert significant protective or ameliorative effects against drug-induced kidney disease, especially against cisplatin-induced renal damage. Whether the protective administration of silymarin could be an effective clinical pharmacological strategy to prevent DIN is a question that remains to be answered in clinical trials.

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J Pharm Pharm Sci, 15 (1): 112-123, 2012

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DOI: http://dx.doi.org/10.18433/J3F88S