Cell-Derived Microparticles: New Targets in the Therapeutic Management of Disease

Authors

  • Mary Bebawy School of Pharmacy, Graduate School of Health, The University of Technology, Sydney, NSW, Australia
  • Ariane Roseblade School of Pharmacy, Graduate School of Health, The University of Technology, Sydney, NSW, Australia
  • Frederick Luk School of Pharmacy, Graduate School of Health, The University of Technology, Sydney, NSW, Australia
  • Tristan Rawling School of Pharmacy, Graduate School of Health, The University of Technology, Sydney, NSW, Australia
  • Alison Ung School of Chemistry and Forensic Science, Faculty of Science, The University of Technology, Sydney, NSW, Australia
  • Georges E. R. Grau Vascular Immunology Unit, Sydney Medical School and Bosch Institute, The University of Sydney, NSW, Australia

DOI:

https://doi.org/10.18433/J3989X

Abstract

Intercellular communication is essential to maintain vital physiological activities and to regulate the organism’s phenotype. There are a number of ways in which cells communicate with one another. This can occur via autocrine signaling, endocrine signaling or by the transfer of molecular mediators across gap junctions. More recently communication via microvesicular shedding has gained important recognition as a significant pathway by which cells can coordinate the spread and dominance of selective traits within a population. Through this communication apparatus, cells can now acquire and secure a survival advantage, particularly in the context of malignant disease. This review aims to highlight some of the functions and implications of microparticles in physiology of various disease states, and present a novel therapeutic strategy through the regulation of microparticle production. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

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Published

2013-06-10

How to Cite

Bebawy, M., Roseblade, A., Luk, F., Rawling, T., Ung, A., & Grau, G. E. R. (2013). Cell-Derived Microparticles: New Targets in the Therapeutic Management of Disease. Journal of Pharmacy & Pharmaceutical Sciences, 16(2), 238–253. https://doi.org/10.18433/J3989X

Issue

Vol. 16 No. 2 (2013)

Section

CLOSED. Special Issue - Chief Guest Editor: Basil D Roufogalis; Co-Guest Editors: Emanuel Strehler & Srinivas Nammi

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