Anaphylactic Reaction to Pemetrexed: A Case Report

Authors

  • Heloise Capelle Oncopharma, Hôpital Nord, AP-HM, Marseille, France
  • Joelle Birnbaum Service de Pneumologie, Hôpital Nord, AP-HM, Marseille, France
  • Pascale Tomasini Oncologie multidisciplinaire et innovations thérapeutiques, Hôpital Nord, AP-HM, Marseille, France
  • Céline Tummino Service de Pneumologie, Hôpital Nord, AP-HM, Marseille, France
  • Marion Gouitaa Service de Pneumologie, Hôpital Nord, AP-HM, Marseille, France
  • Nathalie Ausias Oncopharma, Hôpital Nord, AP-HM, Marseille, France
  • Denis Charpin Service de Pneumologie, Hôpital Nord, AP-HM, Marseille, France
  • Fabrice Barlesi Oncologie multidisciplinaire et innovations thérapeutiques, Hôpital Nord, AP-HM, Marseille, France
  • Marc Montana Oncopharma, Hôpital Nord, AP-HM, Marseille, France

DOI:

https://doi.org/10.18433/J32C8D

Abstract

Pemetrexed is approved to treat non-small cell lung cancer and has an overall favorable toxicity profile. We describe a 58-year-old man who developped an anaphylactic shock within few minutes from the beginning of pemetrexed perfusion. Pemetrexed was discontinued and the patient’s symptoms gradually resolved with administration of symptomatic treatment. Serum tryptase level remained normal and intra dermal skin tests were negative eventhough a nonspecific papule was noted. This case suggests that caution should be exercised when prescribing pemetrexed and clinicians must be warranted for the possibility of serious adverse events associated with pemetrexed use.

 

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Author Biography

Pascale Tomasini, Oncologie multidisciplinaire et innovations thérapeutiques, Hôpital Nord, AP-HM, Marseille, France

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Published

2014-05-19

How to Cite

Capelle, H., Birnbaum, J., Tomasini, P., Tummino, C., Gouitaa, M., Ausias, N., … Montana, M. (2014). Anaphylactic Reaction to Pemetrexed: A Case Report. Journal of Pharmacy & Pharmaceutical Sciences, 17(2), 229–230. https://doi.org/10.18433/J32C8D

Issue

Vol. 17 No. 2 (2014)

Section

Reports

License

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