Antimicrobial and P450 Inhibitory Properties of Common Functional Foods

Authors

  • San Nguyen University of Ottawa
  • Huang Huang Carleton University
  • Brian C Foster University of Ottawa
  • Teresa W Tam University of Ottawa
  • Tim Xing Carleton University
  • Myron L Smith Carleton University
  • John T Arnason University of Ottawa
  • Humayoun Akhtar Agriculture and Agri-Food Canada

DOI:

https://doi.org/10.18433/J3P599

Abstract

PURPOSE:  To study the effect of functional foods on human cytochrome P450 (CYP) and the gut bacterial microflora that may potentially affect drug metabolism and ultimately affect human health and wellness. METHODS: This study examined a variety of food plants from the Apiaceae, Fabaceae, and Lamiaceae families for their inhibitory potential on cytochrome 2D6-, 3A4-, 3A5-, and 3A7-mediated metabolism. The antimicrobial effects of these samples were also investigated with 7 selected bacterial surrogate species to determine potential effects on the gut microflora. RESULTS: The highest CYP inhibitory activities, based upon visual examination, were observed from extracts of celery seed, cumin, fennel seed, basil, oregano, and rosemary belonging to the Apiaceae and Lamiaceae families, respectively. Likewise, the strongest antimicrobial activities were also observed in the Apiaceae and Lamiaceae. No significant antimicrobial and CYP inhibition was observed in the Fabaceae extracts. CONCLUSION: Results demonstrated the possible risk of food-drug interactions from spice and herb plants may affect drug disposition and safety.

 

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Author Biographies

San Nguyen, University of Ottawa

Centre for Research in Biopharmaceuticals and Biotechnology,

Huang Huang, Carleton University

Departmetn of Biology

Brian C Foster, University of Ottawa

Centre for Research in Biopharmaceuticals and Biotechnology, Adjunct Professor

Teresa W Tam, University of Ottawa

Centre for Research in Biopharmaceuticals and Biotechnology,

Tim Xing, Carleton University

Department of Biology, Professor

Myron L Smith, Carleton University

Department of Biology, Professor

John T Arnason, University of Ottawa

Centre for Research in Biopharmaceuticals and Biotechnology, Professor

Humayoun Akhtar, Agriculture and Agri-Food Canada

Guelph Food Research Centre,

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Published

2014-06-08

How to Cite

Nguyen, S., Huang, H., Foster, B. C., Tam, T. W., Xing, T., Smith, M. L., … Akhtar, H. (2014). Antimicrobial and P450 Inhibitory Properties of Common Functional Foods. Journal of Pharmacy & Pharmaceutical Sciences, 17(2), 254–265. https://doi.org/10.18433/J3P599

Issue

Vol. 17 No. 2 (2014)

Section

Pharmaceutical Sciences; Review Articles

License

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