Statins Reduce Mortality After Non-severe but Not After Severe Pneumonia: A Systematic Review and Meta-Analysis

Authors

  • Mingwang Jia Southern Medical University, Guangzhou, Guangdong Province, P. R. China; Department of Respiratory Medicine，Liuhuaqiao Hospital, Guangzhou, Guangdong Province, China; Department of Intensive Care Unit, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, P. R. China.
  • Wenjie Huang Department of Respiratory Medicine，Liuhuaqiao Hospital, Guangzhou, Guangdong Province, China
  • Li Li Department of Respiratory Medicine，Liuhuaqiao Hospital, Guangzhou, Guangdong Province, China
  • Zhong Xu Department of Intensive Care Unit, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, P. R. China
  • Lichan Wu Department of Intensive Care Unit, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, P. R. China

DOI:

https://doi.org/10.18433/J34307

Abstract

PURPOSE: The objective of this study was to perform a systematic review and meta-analysis of the effects of statins on mortality for patients with non-severe pneumonia or severe pneumonia. METHODS: PubMed, EMBASE, Cochrane Database of Systematic Reviews, Cochrane central register of controlled trials and Clinicaltrials.gov were searched for the association between statins and non-severe/severe pneumonia. Eligible articles were analyzed in Stata 12.0. RESULTS: The database search yielded a total of 566 potential publications, 24 studies involving 312,309 patients met the eligibility criteria. Pooled unadjusted data showed that statin use was associated with lower mortality after non-severe pneumonia (odds ratio [OR] 0.70, 95% confidence interval [CI], 0.66-0.73), but not severe pneumonia (OR 1.05; 95% CI, 0.86-1.28). However, this protective effect of statins was weakened using adjusted estimates (OR 0.78, 95% CI, 0.75-0.82). Besides, protective effect of statins was attenuated by confounders in a subgroup analysis, especially when accounting for pneumonia severity indicators (OR 0.88; 95% CI, 0.80-0.96). CONCLUSIONS: Statin use was associated with reduced mortality after non-severe pneumonia but not severe pneumonia and this protective effect was weakened in subgroups.

 

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Author Biography

Wenjie Huang, Department of Respiratory Medicine，Liuhuaqiao Hospital, Guangzhou, Guangdong Province, China

China

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Published

2015-08-13

How to Cite

Jia, M., Huang, W., Li, L., Xu, Z., & Wu, L. (2015). Statins Reduce Mortality After Non-severe but Not After Severe Pneumonia: A Systematic Review and Meta-Analysis. Journal of Pharmacy & Pharmaceutical Sciences, 18(3), 286–302. https://doi.org/10.18433/J34307

Issue

Vol. 18 No. 3 (2015)

Section

Pharmaceutical Sciences; Review Articles

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