The Role of SIRT3 in Mediating Cardioprotective Effects of RAS Inhibition on Cardiac Ischemia-Reperfusion

Authors

  • Sabzali Javadov Department of Physiology, School of Medicine, University of Puerto Rico, San Juan, PR, USA.
  • Nelson Escobales Department of Physiology, School of Medicine, University of Puerto Rico, San Juan, PR, USA.

DOI:

https://doi.org/10.18433/J3NW2K

Abstract

Cardiac ischemia-reperfusion stimulates the renin-angiotensin system (RAS) associated with elevated levels of circulating angiotensin II. Numerous studies demonstrate that the antagonist for the angiotensin II type 1 receptor, losartan improves cardiac function in animal models of ischemia-reperfusion. Molecular mechanisms of the cardioprotective effects of RAS inhibitors on cardiac ischemia-reperfusion remain poorly understood, and are not associated with the anti-hypertensive action of these drugs. This Commentary focuses on the study published in the Journal of Pharmacy and Pharmaceutical Sciences, 2015, 18:112-123, that elucidates the role of SIRT3 in the cardioprotective action of losartan against ischemic-reperfusion injury. We provide comprehensive discussion of the role of mitochondria in the cardioprotective effects of losartan through SIRT3.

 

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Author Biographies

Sabzali Javadov, Department of Physiology, School of Medicine, University of Puerto Rico, San Juan, PR, USA.

Associate Professor, Department of Physiology

Nelson Escobales, Department of Physiology, School of Medicine, University of Puerto Rico, San Juan, PR, USA.

Director & Professor, Department of Physiology

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Published

2015-10-15

How to Cite

Javadov, S., & Escobales, N. (2015). The Role of SIRT3 in Mediating Cardioprotective Effects of RAS Inhibition on Cardiac Ischemia-Reperfusion. Journal of Pharmacy & Pharmaceutical Sciences, 18(3), 547–550. https://doi.org/10.18433/J3NW2K

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Section

Commentaries