Bioavailability Improvement Strategies for Poorly Water-Soluble Drugs Based on the Supersaturation Mechanism: An Update

Authors

  • Meiyan Yang State key Laboratory of Toxicology and Medical Countermeasures, Department of Pharmaceutics, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
  • Wei Gong State key Laboratory of Toxicology and Medical Countermeasures, Department of Pharmaceutics, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
  • Yuli Wang State key Laboratory of Toxicology and Medical Countermeasures, Department of Pharmaceutics, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
  • Li Shan State key Laboratory of Toxicology and Medical Countermeasures, Department of Pharmaceutics, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
  • Ying Li State key Laboratory of Toxicology and Medical Countermeasures, Department of Pharmaceutics, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
  • Chunsheng Gao State key Laboratory of Toxicology and Medical Countermeasures, Department of Pharmaceutics, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.

DOI:

https://doi.org/10.18433/J3W904

Abstract

The formulation development for poorly soluble drugs still remains a challenge. Supersaturating drug delivery systems (SDDS) or drug delivery systems based on supersaturating provide a promising way to improve the oral bioavailability of poorly water-soluble drugs. In supersaturable formulations, drug concentration exceeds the equilibrium solubility when exposed to gastrointestinal fluids, and the supersaturation state is maintained long enough to be absorbed, resulting in compromised bioavailability. In this article, the mechanism of generating and maintaining supersaturation and the evaluation methods of supersaturation assays are discussed. Recent advances in different drug delivery systems based on supersaturating are the focus and are discussed in detail.

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Published

2016-06-16

How to Cite

Yang, M., Gong, W., Wang, Y., Shan, L., Li, Y., & Gao, C. (2016). Bioavailability Improvement Strategies for Poorly Water-Soluble Drugs Based on the Supersaturation Mechanism: An Update. Journal of Pharmacy & Pharmaceutical Sciences, 19(2), 208–225. https://doi.org/10.18433/J3W904

Issue

Vol. 19 No. 2 (2016)

Section

Review Articles

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