Organogels in Drug Delivery: A Special Emphasis on Pluronic Lecithin Organogels

Authors

  • Hashem Alsaab Department of Pharmacy Practice, The University of Toledo, Health Science Campus, 3000 Arlington Ave. Toledo, OH.
  • Sindhu Prabha Bonam Department of Pharmacy Practice, The University of Toledo, Health Science Campus, 3000 Arlington Ave. Toledo, OH.
  • Dherya Bahl Department of Pharmacy Practice, The University of Toledo, Health Science Campus, 3000 Arlington Ave. Toledo, OH.
  • Pallabita Chowdhury Department of Pharmacy Practice, The University of Toledo, Health Science Campus, 3000 Arlington Ave. Toledo, OH.
  • Kenneth Alexander Department of Pharmacy Practice, The University of Toledo, Health Science Campus, 3000 Arlington Ave. Toledo, OH.
  • Sai HS. Boddu Department of Pharmacy Practice, The University of Toledo, Health Science Campus, 3000 Arlington Ave. Toledo, OH.

DOI:

https://doi.org/10.18433/J3V89W

Abstract

Organogels have emerged as an alternative carrier for small and macromolecules via transdermal, oral, rectal and ophthalmic routes. Pluronic lecithin organogels (PLO gels) are lecithin-based organogels widely used in compounding pharmacies as a vehicle for enhancing the transdermal permeability of many therapeutic drugs. However, the scientific and systematic evidence in support of how well PLO gels help in transdermal delivery is scanty. Recently, some clinical studies have reported nearly complete lack of bioavailability of certain topically administered drugs from PLO gels. The present review aims at summarizing gels and organogels, with a focus on the use of PLO gels in transdermal drug delivery. A special emphasis is placed on controversies looming over the use of PLO gels as a delivery platform for drugs via transdermal route.

 

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Published

2016-07-12

How to Cite

Alsaab, H., Bonam, S. P., Bahl, D., Chowdhury, P., Alexander, K., & Boddu, S. H. (2016). Organogels in Drug Delivery: A Special Emphasis on Pluronic Lecithin Organogels. Journal of Pharmacy & Pharmaceutical Sciences, 19(2), 252–273. https://doi.org/10.18433/J3V89W

Issue

Vol. 19 No. 2 (2016)

Section

Review Articles

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