A Short Guide to Electrophysiology and Ion Channels





The birth and discovery of electrophysiological science took place in the 18­­th century laying the path for our understanding of nerve membrane ionic currents. The pore-forming proteins, ion channels, are involved and play critical roles in very important physiological and pathological processes, such as neuronal signaling and cardiac excitability, therefore, they serve as therapeutic drug targets. The study of physiological, pharmacological and biophysical properties of ion channels can be done by patch clamp, a gold standard and powerful electrophysiological technique. The current review, in addition to highlight and cover the history of electrophysiology, patch clamp (conventional and automated) technique, and different types of ion channels, will also discuss the importance of ion channels in different neurological diseases and disorders. As the field of neuroscience is growing, this manuscript is intended as a guide to help in understanding the importance of ion channels, particularly in neuroscience, and also in using the patch clamp technique for the study of molecular physiology, pathophysiology, and pharmacology of neuronal ion channels. Importantly, this review will spotlight on the therapeutic aspect of neuronal ion channels.    


This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.


Download data is not yet available.

Author Biography

Hussein Nori Rubaiy, School of Medicine, The Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, U.K.

I am an ion channel electrophysiologist/pharmacologist, expert in patch clamp technique and a registered pharmacist (several years of experience at the main pharmacy in Sweden). I completed my pharmacy degree from Uppsala University. My bachelor’s and master’s projects were within pharmaceutical pharmacology and the latter was performed as a collaboration with Karolinska Institute working on safety pharmacology (cardiovascular, hERG channel, fetus whole heart). I hold a Ph.D. from the University of Leicester, School of Medicine, UK (cardiovascular and pharmacology department, potassium channels, structure-function).  Following my Ph.D., I continued with post-doctoral studies at Dalhousie University, Canada (CFTR channels, gating). I am currently at the University of Leeds, UK, working on a drug discovery project under an industrial research contract with Max-Planck Institute and Lead Discovery Center, Germany (ion channel pharmacology). My research interest includes drug discovery to study the molecular mechanisms of ion channels in diseases to develop a novel or deliver better ion channel-based therapeutic targets for human disorder and diseases.




How to Cite

Rubaiy, H. N. (2017). A Short Guide to Electrophysiology and Ion Channels. Journal of Pharmacy & Pharmaceutical Sciences, 20, 48–67. https://doi.org/10.18433/J32P6R



Review Articles