Alzheimer’s Disease: Dawn of a New Era?

  • Farideh Amirrad School of Pharmacy, Chapman University, Irvine, CA, USA.
  • Emira Bousoik School of Pharmacy, Chapman University, Irvine, CA, USA.
  • Kiumars Shamloo School of Pharmacy, Chapman University, Irvine, CA, USA.
  • Hassan Al-Shiyab School of Pharmacy, Chapman University, Irvine, CA, USA.
  • Viet-Huong V. Nguyen School of Pharmacy, Chapman University, Irvine, CA, USA.
  • Hamidreza Montazeri Aliabadi School of Pharmacy, Chapman University, Irvine, CA, USA.

Abstract

Alzheimer’s disease (AD) is an irreversible neurodegenerative disease characterized by a progressive decline in cognition and memory, leading to significant impairment in daily activities and ultimately death. It is the most common cause of dementia, the prevalence of which increases with age; however, age is not the only predisposing factor. The pathology of this cognitive impairing disease is still not completely understood, which has limited the development of valid therapeutic options. Recent years have witnessed a wide range of novel approaches to combat this disease, so that they greatly increased our understanding of the disease and of the unique drug development issues associated with this disease. In this paper, we provide a brief overview of the history, the clinical presentation and diagnosis, and we undertake a comprehensive review of the various approaches that have been brought to clinical trials in recent years, including immunotherapeutic approaches, tau-targeted strategies, neurotransmitter-based therapies, neurotropic and hematopoietic growth factors, and antioxidant therapies, trying to highlight the lessons learned from these approaches.

 

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Published
2017-07-26
How to Cite
Amirrad, F., Bousoik, E., Shamloo, K., Al-Shiyab, H., Nguyen, V.-H., & Montazeri Aliabadi, H. (2017). Alzheimer’s Disease: Dawn of a New Era?. Journal of Pharmacy & Pharmaceutical Sciences, 20, 184-225. https://doi.org/10.18433/J3VS8P
Section
Review Articles