Comparison of Ticagrelor with Clopidogrel in Reducing Interleukin-17 and Myeloperoxidase Expression in Thrombus and Improving Postprocedural Coronary Flow in ST-segment Elevation Myocardial Infarction Patients

Authors

  • WenHua Li Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Nangang District, Heilongjiang Province, Harbin, China.
  • SongQi Guo Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Nangang District, Heilongjiang Province, Harbin, China.
  • Shu Wang Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Nangang District, Heilongjiang Province, Harbin, China.
  • Xin Sun Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Nangang District, Heilongjiang Province, Harbin, China.
  • ZhuQin Li Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Nangang District, Heilongjiang Province, Harbin, China.
  • XinYong Sun Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Nangang District, Heilongjiang Province, Harbin, China.
  • YanMing Sun Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Nangang District, Heilongjiang Province, Harbin, China.
  • LanFeng Wang Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Nangang District, Heilongjiang Province, Harbin, China.
  • Wei Pan Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Nangang District, Heilongjiang Province, Harbin, China.

DOI:

https://doi.org/10.18433/jpps29624

Abstract

Purpose. This study aimed to explore the effects of ticagrelor (a P2Y12 receptor inhibitor) on interleukin (IL)-17 and myeloperoxidase (MPO) expression in coronary thrombus as well as on the coronary blood flow in ST-segment elevation myocardial infarction (STEMI) patients following percutaneous coronary intervention (PCI). Methods. Forty STEMI patients who were admitted to the First Affiliated Hospital of Harbin Medical University between August 1, 2014 and December 30, 2014 were enrolled in this study according to a set inclusion criteria. They were randomized to ticagrelor and clopidogrel groups and treated with 180 mg ticagrelor and 600 mg clopidogrel before PCI, respectively. Intracoronary thrombus aspiration was performed by a physician during PCI. Immunohistochemistry and Western blot analysis were carried out to detect the expression of IL-17 and MPO in the thrombus. Corrected thrombolysis in myocardial infarction frame count (CTFC) was used to evaluate blood flow after PCI. Results. Immunohistochemistry results showed that the average positive staining area percentage of IL-17 and MPO in the clopidogrel group was significantly higher than that in the ticagrelor group. Western blot analysis also showed similar results for IL-17 (clopidogrel 0.71 ± 0.036, ticagrelor 0.50 ± 0.56) and MPO (clopidogrel 0.50 ± 0.040; ticagrelor 0.38 ± 0.06). CTFC was lower in the ticagrelor group than that in the clopidogrel group (P < 0.05). Conclusions. Ticagrelor is more effective than clopidogrel in reducing inflammation thrombosis and improving postprocedural PCI blood flow in STEMI patients.

 

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Published

2018-06-12

How to Cite

Li, W., Guo, S., Wang, S., Sun, X., Li, Z., Sun, X., … Pan, W. (2018). Comparison of Ticagrelor with Clopidogrel in Reducing Interleukin-17 and Myeloperoxidase Expression in Thrombus and Improving Postprocedural Coronary Flow in ST-segment Elevation Myocardial Infarction Patients. Journal of Pharmacy & Pharmaceutical Sciences, 21(1), 207–216. https://doi.org/10.18433/jpps29624

Issue

Section

Clinical Pharmacology and Therapeutics