Role of differential proteomics in studying pharmacological mechanisms of traditional Chinese medicines
DOI:
https://doi.org/10.18433/jpps30429Abstract
Traditional Chinese Medicines (TCMs) have been used for more than 3,000 years. However, most TCMs are used based on previous experience, and their exact mechanisms are still unclear. Proteomics, as a major component of systems biology, is an appropriate tool that could bring breakthroughs in the study of pharmacological mechanisms of TCMs. Researchers made substantial progress by using the proteomics approach to investigate the mechanism of TCMs. In this review, we summarize the current applications of proteomics in the mechanistic study of TCMs. Proteomics technologies and strategies that might be used in the future to enhance the study of TCMs are also discussed.Downloads
References
Ji Q, Zhu F, Liu X, Li Q, Su SB. Recent Advance in Applications of Proteomics Technologies on Traditional Chinese Medicine Research. Evidence-Based Complementary and Alternative Medicine. 2015;2015(Print): 1-13.
Chang YH, Ye L, Cai W, et al. Quantitative Proteomics Reveals Differential Regulation of Protein Expression in Recipient Myocardium after Trilineage Cardiovascular Cell Transplantation. Proteomics. 2015;15(15): 2560-2567.
Ning J, Hong-Fang L, Si-Di L, et al. An integrated metabonomic and proteomic study on Kidney-Yin Deficiency Syndrome patients with diabetes mellitus in China. Acta Pharmacologica Sinica. 2015;36(6): 689-698.
Shu-Xiang Z, Hui S, Wen-Jun S, Guo-Zheng J, Xi-Jun W. Proteomic study of serum proteins in a type 2 diabetes mellitus rat model by Chinese traditional medicine Tianqi Jiangtang Capsule administration. J Pharm Biomed Anal. 2010;53(4): 1011-1014.
Cho WCS, Yip TT, Chung WS, et al. Altered expression of serum protein in ginsenoside Re-treated diabetic rats detected by SELDI-TOF MS. Journal of Ethnopharmacology. 2006;108(2): 272-279.
Shi X, ., Lu XG, Zhan LB, et al. The effects of the Chinese medicine ZiBu PiYin recipe on the hippocampus in a rat model of diabetes-associated cognitive decline: a proteomic analysis. Diabetologia. 2011;54(7): 1888-1899.
Gong G, Yuan H, Liu Y, Qi L. Investigation of the Effects and Mechanisms of Mai Tong Formula on Lower Limb Macroangiopathy in a Spontaneous Diabetic Rat Model. Journal of Diabetes Research. 2016;2016(4): 1-8.
Li Q, Cui HH, Yang YJ, et al. Quantitative Proteomics Analysis of Ischemia/Reperfusion Injury-Modulated Proteins in Cardiac Microvascular Endothelial Cells and the Protective Role of Tongxinluo. Cellular Physiology & Biochemistry. 2017;41(4): 1503-1518.
Liu XX, Tang L, Ge R, et al. iTRAQ-based quantitative proteomic analysis of the anti-apoptotic effect of hyperin, which is mediated by Mcl-1 and Bid, in H2O2-injured EA.hy926 cells. International Journal of Molecular Medicine. 2016;37(4): 1083.
Feng L, Manavalan A, Mishra M, Sze SK, Hu JM, Heese K. Tianma modulates blood vessel tonicity. Open Biochemistry Journal. 2012;6(1): 56-65.
Yue QX, Xie FB, Song XY, et al. Proteomic studies on protective effects of salvianolic acids, notoginsengnosides and combination of salvianolic acids and notoginsengnosides against cardiac ischemic-reperfusion injury. Journal of Ethnopharmacology. 2012;141(2): 659-667.
Yan Y, Wu WY, Guan SH, et al. Proteomic analysis of differential protein expression in rat platelets treated with notoginsengnosides. Phytomedicine International Journal of Phytotherapy & Phytopharmacology. 2008;15(10): 800-807.
Li-Xing F, Chun-Jie J, Kai-Lin T, et al. Clarifying the signal network of salvianolic acid B using proteomic assay and bioinformatic analysis. Proteomics. 2011;11(8): 1473-1485.
Chao M, Yan Y, Qing-Xi Y, et al. Differential proteomic analysis of platelets suggested possible signal cascades network in platelets treated with salvianolic acid B. Plos One. 2011;6(2): e14692.
Jia YH, Zhang YX, Li LJ, et al. Dingxin recipe prevents ischemia/reperfusion-induced arrhythmias via up-regulating prohibitin and suppressing inflammatory responses. Chinese Journal of Integrative Medicine. 2012;18: 120-129.
Ping Z, Bin L, Qun W, et al. Apigenin Attenuates Atherogenesis through Inducing Macrophage Apoptosis via Inhibition of AKT Ser473 Phosphorylation and Downregulation of Plasminogen Activator Inhibitor-2. Oxidative Medicine and Cellular Longevity.2015;2015:379538
Liu Z, Huang J, Huo Y, et al. Identification of Proteins Implicated in the Increased Heart Rate in ShenSongYangXin-Treated Bradycardia Rabbits by iTRAQ-Based Quantitative Proteomics. Evidence-Based Complementray and Alternative Medicine. 2015;2015(18, supplement 3): 1-7.
Fan X, Li XS, Wang Y, Zhao Y, Luo G. Comparative proteomics research on rat MSCs differentiation induced by Shuanglong Formula. Journal of Ethnopharmacology. 2010;131(3): 575-580.
Chen YY, Li Q, Pan CS, et al. QiShenYiQi Pills, a compound in Chinese medicine, protects against pressure overload-induced cardiac hypertrophy through a multi-component and multi-target mode. Scientific Reports. 2015;5(JUL 2): 11802.
Ramachandran U, Manavalan A, Sundaramurthi H, et al. Tianma modulates proteins with various neuro-regenerative modalities in differentiated human neuronal SH-SY5Y cells. Neurochemistry International. 2012;60(8): 827-836.
Manavalan A, Ramachandran U, Sundaramurthi H, et al. Gastrodia elata Blume (tianma) mobilizes neuro-protective capacities. Int J Biochem Mol Biol. 2012;3(3): 219-241.
Lo WY, Tsai FJ, Liu CH, et al. Uncaria rhynchophylla Upregulates the Expression of MIF and Cyclophilin A in Kainic Acid-Induced Epilepsy Rats: A Proteomic Analysis. Am J Chin Med. 2010;38(04): 745-759.
Yimin T, Li F, Yiming Y, et al. Quantitative proteomic analysis reveals the neuroprotective effects of huperzine A for amyloid beta treated neuroblastoma N2a cells. Proteomics. 2013;13(8): 1314-1324.
Koh PO. Identification of Proteins Differentially Expressed in Cerebral Cortexes of Ginkgo biloba Extract (EGb761)-Treated Rats in a Middle Cerebral Artery Occlusion Model — A Proteomics Approach. American Journal of Chinese Medicine. 2011;39(02): 315-324.
Zhang Z, Wu R, Li P, et al. Baicalin administration is effective in positive regulation of twenty-four ischemia/reperfusion-related proteins identified by a proteomic study. Neurochemistry International. 2009;54(8): 488-496.
Chen HJ, Shen YC, Shiao YJ, et al. Multiplex Brain Proteomic Analysis Revealed the Molecular Therapeutic Effects of Buyang Huanwu Decoction on Cerebral Ischemic Stroke Mice. Plos One. 2015;10(10): e0140823.
Ying CZ, Liu B, Ying JL, et al. Effects of Buyang Huanwu Decoction on Ventricular Remodeling and Differential Protein Profile in a Rat Model of Myocardial Infarction. Evidence-Based Complementray and Alternative Medicine, 2012;2012(2): 385247.
Nagai T, Nakao M, Shimizu Y, et al. Proteomic Analysis of Anti-inflammatory Effects of a Kampo (Japanese Herbal) Medicine “Shoseiryuto (Xiao-Qing-Long-Tang)” on Airway Inflammation in a Mouse Model. Evidence-Based Complementray and Alternative Medicine. 2010;2011(2): 604196.
Hernandezgea V, Friedman SL. Pathogenesis of liver fibrosis. Annu Rev Pathol. 2011;6(1): 425-456.
Pan TL, Wang PW, Huang CH, et al. Herbal formula, Scutellariae radix and Rhei rhizoma attenuate dimethylnitrosamine-induced liver fibrosis in a rat model. Scientific Reports. 2015;5: 11734.
Tai-Long P, Tung-Ho W, Pei-Wen W, et al. Functional proteomics reveals the protective effects of saffron ethanolic extract on hepatic ischemia-reperfusion injury. Proteomics. 2013;13(15): 2297-2311.
Sun H, Zhang A, Yan G, et al. Proteomics study on the hepatoprotective effects of traditional Chinese medicine formulae Yin-Chen-Hao-Tang by a combination of two-dimensional polyacrylamide gel electrophoresis and matrix-assisted laser desorption/ionization-time of flight mass spectrome. Journal of Pharmaceutical & Biomedical Analysis. 2013;75(5): 173-179.
Lee TY, Chang HH, Kuo JJ, Shen JJ. Changes of hepatic proteome in bile duct ligated rats with hepatic fibrosis following treatment with Yin-Chen-Hao-Tang. International Journal of Molecular Medicine. 2009;23(4): 477-484.
Song YN, Dong S, Wei B, Liu P, Zhang YY, Su SB. Metabolomic mechanisms of gypenoside against liver fibrosis in rats: An integrative analysis of proteomics and metabolomics data. Plos One. 2017;12(3): e0173598.
Xue-Gang S, Xiu-Qiong F, Hong-Bing C, et al. Proteomic analysis of protective effects of polysaccharides from Salvia miltiorrhiza against immunological liver injury in mice. Phytotherapy Research. 2011;25(7): 1087-1094.
Wang PW, Hung YC, Li WT, Yeh CT, Pan TL. Systematic revelation of the protective effect and mechanism of Cordycep sinensis on diethylnitrosamine-induced rat hepatocellular carcinoma with proteomics. Oncotarget. 2016;7(37): 60270-60289.
Ma ZJ, Wang XX, Gang S, et al. Proteomic analysis of apoptosis induction by lariciresinol in human HepG2 cells. Chem Biol Interact. 2016;256: 209-219.
Fu WM, Zhang JF, Wang H, et al. Apoptosis induced by 1,3,6,7-tetrahydroxyxanthone in Hepatocellular carcinoma and proteomic analysis. Apoptosis. 2012;17(8): 842-851.
Fu WM, Zhang JF, Wang H, et al. Heat shock protein 27 mediates the effect of 1,3,5-trihydroxy-13,13-dimethyl-2H-pyran [7,6-b] xanthone on mitochondrial apoptosis in hepatocellular carcinoma Journal of Proteomics. 2012;75(15): 4833-4843.
Yoo DR, Chong SA, Nam MJ. Proteome profiling of arsenic trioxide-treated human hepatic cancer cells. Cancer Genomics & Proteomics. 2009;6(5): 269.
Shen DZ, Tao Q, Jin-Xing DU, et al. Effects of Yiguanjian Decoction on liver cirrhosis formation:a differential proteomics study in rats. Zhong XI Yi Jie He Xue Bao. 2010;8(2): 158-167.
Hongdong X, Yanyan T, Jing L, Ping L, Chenghai L. Proteomic analysis of the effect of fuzheng huayu recipe on fibrotic liver in rats. Evid Based Complement Alternat Med. 2013;2013(1): 972863.
Fang HY, Chen SB, Guo DJ, Pan SY, Yu ZL. Proteomic identification of differentially expressed proteins in curcumin-treated MCF-7 cells. Phytomedicine. 2011;18(8-9): 697-703.
D'Aguanno S, D'Agnano I, Canio MD, et al. Shotgun proteomics and network analysis of neuroblastoma cell lines treated with curcumin. Molecular Biosystems. 2012;8(4): 1068-1077.
Tan Y, Goh D, Es. Investigation of differentially expressed proteins due to the inhibitory effects of berberine in human liver cancer cell line HepG2. Molecular Biosystems. 2006;2(5): 250-258.
Cho CS. Application of Proteomics in Chinese Medicine Research. American Journal of Chinese Medicine. 2007;35(06): 911-922.
Yue Q, Cao Z, Guan S, et al. Proteomics characterization of the cytotoxicity mechanism of ganoderic acid D and computer-automated estimation of the possible drug target network. Molecular & Cellular Proteomics. 2008;7(5): 949-961.
Tai-Long P, Yu-Chiang H, Pei-Wen W, et al. Functional proteomic and structural insights into molecular targets related to the growth inhibitory effect of tanshinone IIA on HeLa cells. Proteomics. 2010;10(5): 914-929.
Hong-Zin L, Chun-Hsiung W, Shen-Peng C. Release of nucleophosmin from the nucleus: Involvement in aloe-emodin-induced human lung non small carcinoma cell apoptosis. International Journal of Cancer. 2010;113(6): 971-976.
Huang WS, Kuo YH, Chin CC, et al. Proteomic analysis of the effects of baicalein on colorectal cancer cells. Proteomics. 2012;12(6): 810-819.
Zi L, Liang M, Guang-Biao Z. The main anticancer bullets of the Chinese medicinal herb, thunder god vine. Molecules. 2011;16(6): 5283.
Liu Y, Song F, Wu WK, et al. Triptolide inhibits colon cancer cell proliferation and induces cleavage and translocation of 14-3-3 epsilon. Cell Biochemistry & Function. 2012;30(4): 271-278.
Hansen J, Palmfeldt J, Vang S, Corydon TJ, Gregersen N, Bross P. Quantitative proteomics reveals cellular targets of celastrol. Plos One. 2011;6(10): e26634.
Cheng z, Liu BR, Qian, XP, Ding, YT, Hu, WJ, Sun, J, Yu, LX. Proteomic analysis of anti-tumor effects by Rhizoma Paridis total saponin treatment in HepG2 cells. J Ethnopharmacol. 2008;120(2): 129-137.
Liu ZY, Huang J, Liu NN, et al. Molecular Mechanisms of Increased Heart Rate in Shenxianshengmai-treated Bradycardia Rabbits. Chinese Medical Journal. 2017;130(2): 179-186.
Cui G, Ho AW, Lee SMY, Wang Y, Hoi MPM. Development of the novel antiplatelet agent ADTM, originating from traditional Chinese medicine: a chemical proteomic analysis and in-vivo assessment of efficacy in an animal model. Lancet. 2016;388: S37-S37.
Zeng P, Liu B, Wang Q, et al. Apigenin Attenuates Atherogenesis through Inducing Macrophage Apoptosis via Inhibition of AKT Ser473 Phosphorylation and Downregulation of Plasminogen Activator Inhibitor-2. Oxidative Medicine & Cellular Longevity. 2015;2015(1-2): 379538.
Yang MH, Zeng-Chun MA, Dou YQ, et al. Effects of Siwu tang on serum protein of blood deficiency using proteomic technique. China Journal of Chinese Materia Medica. 2008;33(4): 420-423.
Liu LL, Zeng-Chun MA, Wang YG, et al. Effects of Siwu decoction on bone marrow protein expression of blood deficiency mice induced by cyclophosphamide. China journal of Chinese materia medica. 2006;31(14): 1172.
Guo P, Zeng chun MA, Ying fei LI, Liang QD, Feng WAJ, Wang SQ. Effects of Siwu Tang on protein expression of bone marrow of blood deficiency mice induced by irradiation. China journal of Chinese materia medica. 2004;29(9): 893.
Yao Y, Wu WY, Liu AH, et al. Interaction of Salvianolic Acids and Notoginsengnosides in Inhibition of ADP-Induced Platelet Aggregation. American Journal of Chinese Medicine. 2008;36(02): 0800579-.
Zhang T, Li DK, Changsha. Effect of Yizhi Jiannao Granule Concentration Fluid on the Differential Expression Protein in Entorhinal Area Tissue of Senescence Accelerated Mouse P8. Chinese Journal of Integrated Traditional & Western Medicine. 2010;30(5): 504.
Pei-Zheng Z, Kan-Kan W, Qun-Ye Z, et al. Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America. 2005;102(21): 7653-7658.
Fan R, He F, Wang Y, Zhong GW. Changes of protein expression profile in vascular tissues of spontaneously hypertensive rats treated by a compound Chinese herbal medicine. Journal of Chinese Integrative Medicine. 2011;9(6): 643-650.
Hui S, Aihua Z, Guangli Y, et al. Proteomics study on the hepatoprotective effects of traditional Chinese medicine formulae Yin-Chen-Hao-Tang by a combination of two-dimensional polyacrylamide gel electrophoresis and matrix-assisted laser desorption/ionization-time of flight mass spectrome. Journal of Pharmaceutical & Biomedical Analysis. 2013;75(5): 173-179.
Zhang A, Sun H, Yuan Y, Sun W, Jiao G, Wang X. An in vivo analysis of the therapeutic and synergistic properties of Chinese medicinal formula Yin-Chen-Hao-Tang based on its active constituents. Fitoterapia. 2011;82(8): 1160-1168.
Dezhao LU, Xingde WO, Like WO, Yi LI, Tang L, Zhen Y. Effects of warm and tonify kidney-yang herbs on liver mitochondria proteome of kidney-yang deficiency rats. Chinese Pharmaceutical Journal. 2009;34(10): 1251.
Zhang Y, Chen ZQ. Adrenal protein expressions after Pinggan Qianyang Formula treatment in hypertensive rats with liver-yang hyperactivity:a comparative proteomic analysis. Journal of Chinese Integrative Medicine. 2008;6(7): 729.
Mao Q, Zhang PH, Yang J, et al. iTRAQ-Based Proteomic Analysis of Ginsenoside F2 on Human Gastric Carcinoma Cells SGC7901. Evidence-Based Complementary and Alternative Medicine. 2016;2016: 1-21.
Jin T, Yan N, Hou Y, et al. Chemomics-Integrated Proteomics Analysis of Jie-Geng-Tang to Ameliorate Lipopolysaccharide-Induced Acute Lung Injury in Mice. Evidence-Based Complementary and Alternative Medicine. 2016;2016(19): 1-12.
Nooshinfar E, Bashash D, Safaroghli-Azar A, et al. Melatonin promotes ATO-induced apoptosis in MCF-7 cells: Proposing novel therapeutic potential for breast cancer. Biomedicine & Pharmacotherapy. 2016;83: 456-465.
Chou HC, Lu YC, Cheng CS, et al. Proteomic and redox-proteomic analysis of berberine-induced cytotoxicity in breast cancer cells. Journal of Proteomics. 2012;75(11): 3158-3176.
Zhang L, Yu Z, Wang Y, et al. Quantitative proteomics reveals molecular mechanism of gamabufotalin and its potential inhibition on Hsp90 in lung cancer. Oncotarget. 2016;7(47): 76551-76564.
Lai M, Hour MCL, H, Yang W, Lee H. Chaperones are the target in aloe-emodin-induced human lung nonsmall carcinoma H460 cell apoptosis. European Journal of Pharmacology. 2007;573(1): 1-10.
Liu JJ, Wang D, Yu-Hua LI, Meng J, Mei QB, Wang ZP. Effect of Triptolide on Gene Expression Profile of Colon Cancer Cells SW480. Progress in Modern Biomedicine. 2012.
Zhang H, Jian S, Shi J. Screen anti-influenza virus serum marker of Lonicera japonica by proteomics technology. China journal of Chinese materia medica. 2011;36(8): 1071.
Li YL, Zhang XY, Leng Y, Wu YL, Li J, Wu YX. Global protein expression analysis of molecular markers of DS-1-47, a component of implantation-promoting traditional chinese medicine. journal of Huazhong University of Science and Technology [Medical Sciences] 2016;36(6): 910-915.
Bo-cheng L, Xiao-lin S, Chun-wen L, et al. Identification of Human Serum Protein Targets of Qianggu Decoction in Primary Type Ⅰ Osteoporosis Based on Tandem Mass Tag Labeling and Liquid Chromatography-Tandem Mass Spectrometry Technology. Chinese Journal of Integrative Medicine. 2016(10): 29-36.
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