Medicinal Plants as Potential Hemostatic Agents
DOI:
https://doi.org/10.18433/jpps30446Abstract
Purpose: Medicinal plants with a variety of phytochemical ingredients remain a potential source for new drug discovery. The use of medicinal herbs in a wide range of diseases and symptoms, such as bleeding, is prevalent in traditional and ethno medicine worldwide. Thus, this work provides a comprehensive review of medicinal plants or their isolated compounds, with respect to their ethno-medicinal use, which have demonstrated the stimulating effect on the hemostasis process. Methods: The relevant studies were withdrawn from electronic databases including Pubmed, EMBASE and Web of Science with a structured search methodology. Results: The total of 17 medicinal plants with hemostatic activity were extracted. The most frequently studied plant families were Compositae, Lamiaceae, Fabaceae, and Asteraceae. Bioactive compounds exerting hemostatic activity included tannins, iridoid glycosides, glycoconjugate, lignan, saponins and phenolic compounds. The most attributed mechanisms include coagulation stimulation via increasing the factor XII activity and plasma fibrinogen levels, the fibrinolysis inhibition, vascular or smooth muscle constriction and platelet aggregation. The most important adverse effects of high dose extract or isolated compounds administration were hepatotoxicity and nephrotoxicity. Conclusion: This review provides a list of medicinal plants with hemostatic activity that could be used as valuable sources of new plant-based hemostatic agents. Furthermore, this could be practical in detecting possible interactions of plants with anticoagulant, antiplatelet, fibrinolytic and antifibrinolytic medications.
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Beshir SA, Yap L Bin, Sim S, Chee KH, Lo YL. Assessment of predicted rate and associated factors of dabigatran-induced bleeding events in malaysian patients with non-valvular atrial fibrillation. J Pharm Pharm Sci, 2017; 20 (1): 365-377. Doi: 10.18433/J3TP9Q.
Golebiewska EM, Poole AW. Platelet secretion: from haemostasis to wound healing and beyond. Blood Rev, 2015. Doi: 10.1016/j.blre.2014.10.003.
Chapin JC, Hajjar KA. Fibrinolysis and the control of blood coagulation. Blood Reviews, 2015. Doi: 10.1016/j.blre.2014.09.003.
Binazon O, Dubois-Gaché A, Nanau RM, Neuman MG. Efficacy and safety of platelet inhibitors. J Pharm Pharm Sci, 2012. Doi: 10.18433/J3MP4Z.
Rau JC, Beaulieu LM, Huntington JA, Church FC. Serpins in thrombosis, hemostasis and fibrinolysis. J Thromb Haemostasis, 2007. Doi: 10.1111/j.1538-7836.2007.02516.x.
Mankad M.B.B.S PS, odispoti MC. The role of fibrin sealants in hemostasis. Am J Surg, 2001. Doi: 10.1016/S0002-9610(01)00773-5.
Bak JB, Singh A, Shekarriz B. Use of gelatin matrix thrombin tissue sealant as an effective hemostatic agent during laparoscopic partial nephrectomy. J Urol, 2004. Doi: 10.1097/01.ju.0000104800.97009.c6.
Levi MM, Vink R, de Jonge E. Management of bleeding disorders by prohemostatic therapy. Int J Hematol, 2002. Doi: 10.1007/BF03165104.
De Koninck P, Sarhan F, Mateescu MA, Archambault D, Hamel F. Carboxymethyl-Starch Excipients for Gastrointestinal Stable Oral Protein Formulations Containing Protease Inhibitors. J Pharm Pharm Sci, 2016. Doi: 10.18433/J3B01F.
Al-Snafi AE. The chemical constituents and pharmacological effects of Capsella bursa-pastoris-A review. Int J Pharmacol Toxicol, 2015; 5(2):76–81.
Sukmawan YP, Suhendy H. Haemostatic effect of ethanolic extract of ageratum conyzoides l to strains of mice male swiss webster induced with combination of aspirin, clopidogrel and enoxaparin. Asian J Pharm Clin Res, 2017; 10(7):276. Doi: 10.22159/ajpcr.2017.v10i7.18573.
O.Bamidele. Haemostatic effect of methanolic leaf extract of Ageratum conyzoides in albino rats. J Med Plants Res, 2010.
Wang B, Sui J, Yu Z, Zhu L. Screening the hemostatic active fraction of Artemisia annua L. in-vitro. Iran J Pharm Res, 2011.
Pereira B, Brazón J. Aqueous extract from Brownea grandiceps flowers with effect on coagulation and fibrinolytic system. J Ethnopharmacol, 2015. Doi: 10.1016/j.jep.2014.11.022.
Soltani R, Haghighat A, Fanaei M, Asghari G. Evaluation of the effect of green tea extract on the prevention of gingival bleeding after posterior mandibular teeth extraction: A randomized controlled trial. Evidence-based Complement Altern Med, 2014. Doi: 10.1155/2014/857651.
Ghalandari S, Kariman N, Sheikhan Z, Mojab F, Mirzaei M, Shahrahmani H. Effect of Hydroalcoholic Extract of Capsella bursa pastoris on Early Postpartum Hemorrhage: A Clinical Trial Study. J Altern Complement Med, 2017. Doi: 10.1089/acm.2017.0095.
Pandith H, Thongpraditchote S, Wongkrajang Y, Gritsanapan W. In vivo and in vitro hemostatic activity of Chromolaena odorata leaf extract. Pharm Biol, 2012. Doi: 10.3109/13880209.2012.656849.
Li M, Jia Z, Hu Z, Zhang R, Shen T. Experimental study on the hemostatic activity of the Tibetan medicinal herb Lamiophlomis rotata. Phyther Res, 2008. Doi: 10.1002/ptr.2359.
Edemeka DBU, Ogwu AS. Blood Coagulation Activities of the Leaf Extracts of Ocimum gratissimum Plant in Man. J Herbs Spices Med Plants, 2000; 30;7(4):9–14. Doi: 10.1300/J044v07n04_02.
White CM, Fan C, Song J, Tsikouris JP, Chow M. An evaluation of the hemostatic effects of hydrophilic, alcohol, and lipophilic extracts of notoginseng. Pharmacotherapy, 2001. Doi: 10.1592/phco.21.9.773.34561.
Wang Y, Hao J, Gao W, Liu Z, Wu S, Jing S. Study on hemostatic activities of the rhizome of Paris bashanensis. Pharm Biol, 2013. Doi: 10.3109/13880209.2013.790065.
Páez X, Hernández L. Topical hemostatic effect of a common ornamental plant, the geraniaceae Pelargonium zonale. J Clin Pharmacol, 2003. Doi: 10.1177/0091270002251019.
Jaiarj P, Wongkrajang Y, Thongpraditchote S, Peungvicha P, Bunyapraphatsara N, Opartkiattikul N. Guava leaf extract and topical haemostasis. Phyther Res, 2000. Doi: 10.1002/1099-1573(200008)14:5<388::AID-PTR638>3.0.CO;2-K.
Salawu A, Aliyu M, Ay T. Haematological studies on the ethanolic stem bark extract of Pterocarpus erinaceus poir ( fabaceae ). Afr J Biotechnol, 2008. Doi: 10.1111/j.1600-051X.2007.01184.x.
Ediriweera ERHSS, Jayakody JRAC, Ratnasooriya WD. Pro blood clotting activity of Scoparia dulcis in rats. Ayu, 2011. Doi: 10.4103/0974-8520.92547.
Dasgupta N, Ranjan S, Shree M, Saleh MAAM, Ramalingam C. Blood coagulating effect of marigold (Tagetes erecta L.) leaf and its bioactive compounds. Orient Pharm Exp Med, 2016. Doi: 10.1007/s13596-015-0200-z.
Ikese CO, Okoye ZC, Kukwa DT, Adoga SO, Lenka JL. Effect of aqueous leaf extract of Tridax procumbens on blood coagulation. Int J Pharm Sci Res, 2015;6(8):3391.
Ohkura N, Tamura K, Tanaka A, Matsuda J, Atsumi GI. Experimental study on the hemostatc activity of Pollen Typhae: A traditional folk medicine used by external and oral application. Blood Coagul Fibrinolysis, 2011. Doi: 10.1097/MBC.0b013e328349a22c.
Pereira B, Brazón J, Rincón M, Vonasek E. Browplasminin, a condensed tannin with anti-plasmin activity isolated from an aqueous extract of Brownea grandiceps Jacq. flowers. J Ethnopharmacol, 2017. Doi: 10.1016/j.jep.2017.01.012.
Li M, Zhang R, Jia Z, Sheng J, Qiu J, Wang J. Isolation and identification of hemostatic ingredients from Lamiophlomis rotata (Benth.) Kudo. Phyther Res, 2009. Doi: 10.1002/ptr.2669.
Fan PC, Ma HP, Hao Y, He XR, Sun AJ, Jiang W, et al. A new anti-fibrinolytic hemostatic compound 8-O-acetyl shanzhiside methylester extracted from Lamiophlomis rotata. J Ethnopharmacol, 2016. Doi: 10.1016/j.jep.2016.04.016.
Pawlaczyk I, Czerchawski L, Kańska J, Bijak J, Capek P, Pliszczak-Król A, et al. An acidic glycoconjugate from Lythrum salicaria L. with controversial effects on haemostasis. J Ethnopharmacol, 2010. Doi: 10.1016/j.jep.2010.06.001.
Zhang Y, Xie P, Guo X, Kang W. Procoagulant Substance and Mechanism of Myristica fragrans. J Med Food, 2016. Doi: 10.1089/jmf.2016.3700.
White CM, Fan C, Chow M. An evaluation of the hemostatic effect of externally applied notoginseng and notoginseng total saponins. J Clin Pharmacol, 2000. Doi: 10.1592/phco.21.9.773.34561.
Lin Z, Fang Y, Huang A, Chen L, Guo S, Chen J. Chemical constituents from Sedum aizoon and their hemostatic activity. Pharm Biol, 2014. Doi: 10.3109/13880209.2014.895019.
Okunade AL. Ageratum conyzoides L. (Asteraceae). Fitoterapia, 2002. Doi: 10.1016/S0367-326X(01)00364-1.
Brown GD. The biosynthesis of artemisinin (Qinghaosu) and the phytochemistry of artemisia annua L. (Qinghao). Molecules, 2010. Doi: 10.3390/molecules15117603.
Pan X, Niu G, Liu H. Microwave-assisted extraction of tea polyphenols and tea caffeine from green tea leaves. Chem Eng Process, 2003. Doi: 10.1016/S0255-2701(02)00037-5.
Pandith H, Zhang X, Liggett J, Min K-W, Gritsanapan W, Baek SJ. Hemostatic and Wound Healing Properties of Chromolaena odorata Leaf Extract. Int Sch Res Not, 2013. Doi: 10.1155/2013/168269.
Tunalier Z, Koşar M, Küpeli E, Çaliş I, Başer KHC. Antioxidant, anti-inflammatory, anti-nociceptive activities and composition of Lythrum salicaria L. extracts. J Ethnopharmacol, 2007. Doi: 10.1016/j.jep.2006.10.024.
Edeoga HO, Omosun G, Uche LC. Chemical composition of Hyptis suaveolens and Ocimum gratissimum hybrids from Nigeria. J Biotechnol, 2006. Doi: 10.4314/ajb.v5i10.42928.
Dong TTX, Cui XM, Song ZH, Zhao KJ, Ji ZN, Lo CK, et al. Chemical assessment of roots of Panax notoginseng in China: Regional and seasonal variations in its active constituents. J Agric Food Chem, 2003. Doi: 10.1021/jf034229k.
Gutiérrez RMP, Mitchell S, Solis RV. Psidium guajava: A review of its traditional uses, phytochemistry and pharmacology. J Ethnopharmacol, 2008. Doi: 10.1016/j.jep.2008.01.025.
Gabriel AF, Onigbanjo HO. Phytochemical and Antimicrobial Screening of the Stem Bark Extracts of Pterocarpus erinaceus ( Poir ). Niger J Basic Appl, 2010.
Pari L, Latha M. Protective role of Scoparia dulcis plant extract on brain antioxidant status and lipidperoxidation in STZ diabetic male Wistar rats. BMC Complement Altern Med, 2004. Doi: 10.1186/1472-6882-4-16.
Mitich LM. Common Cattail, Typha latifolia L. Weed Technol, 2000; 14(2):446–50.
Halberstein RA. Medicinal plants: Historical and cross-cultural usage patterns. Ann Epidemiol, 2005. Doi: 10.1016/j.annepidem.2005.02.004.
Chitlur, M. Challenges in the laboratory analyses of bleeding disorders. Thromb Res, 2012. Doi: 10.1016/j.thromres.2012.03.011.
Doutremepuich, F., Aguejouf, O., Belougne-Malfatti, E., Doutremepuich, C. Fibrinogen as a factor of thrombosis: experimental study. Thromb Res, 1998; 90, 57–64. Doi: 10.1016/S0049-3848(98)00025-5.
Chukwumah Y, Walker L, Vogler B, Verghese M. Changes in the phytochemical composition and profile of raw, boiled, and roasted peanuts. J Agric Food Chem, 2007. Doi: 10.1021/jf071877l.
Shivaprasad H V, Rajesh R, Vishwanath BS. Hemostatic interference of plant latex proteases. SM J Clin Pathol, 2016; 1(1):1–7.
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