Droperidol Reduces Postoperative Nausea and Vomiting and Supports the Continuation of Intravenous Patient-Controlled Analgesia with Fentanyl

Authors

  • Ikkou Hirata Department of Pharmacy, Kameda General Hospital, Chiba, Japan.
  • Masahiro Iwamoto Department of Pharmacy, Kameda General Hospital, Chiba, Japan.
  • Hiroki` Matsui Clinical Research Unit, Kameda Medical Hospital/Kameda College of Health Science, Chiba, Japan.
  • Hiromi Yoshinuma Department of Anesthesiology, Kameda General Hospital, Chiba, Japan.
  • Ryohkan Funakoshi Department of Pharmacy, Kameda General Hospital, Chiba, Japan.

DOI:

https://doi.org/10.18433/jpps30902

Abstract

PURPOSE: To examine the impact of adding droperidol to fentanyl-based intravenous patient-controlled analgesia (IVPCA) on the discontinuation of IVPCA use due to postoperative nausea and vomiting (PONV). METHODS: Patients who underwent surgeries other than abdominal surgeries and used IVPCA between April 2014 and March 2018 were selected. Patients using IVPCA with fentanyl alone were compared to patients using droperidol added to IVPCA. Patients were allocated to one of two groups depending on the drug used for IVPCA: 1) control group, fentanyl alone; 2) droperidol group, droperidol with fentanyl. The primary endpoint was the discontinuation of IVPCA due to PONV. Secondary endpoints included PONV within 48 hours after surgery, the number of antiemetics used, pain score, and adverse effects. Propensity score matching was used to control the differences in clinical features among patients. RESULTS: Among the 793 patients initially enrolled in this study, 145 were excluded via propensity score matching; 364 of the remaining patients received IVPCA supplemented with droperidol. Propensity score matching showed that discontinuation of IVPCA due to PONV was significantly decreased in the droperidol group compared to the control group (P = 0.01). Further, compared with the control group, the droperidol group had reduced nausea up to 24 hours after surgery (P < 0.01), and the number of vomiting episodes and use of antiemetics decreased within 12 hours after surgery (P < 0.01). CONCLUSIONS: The addition of droperidol to IVPCA is associated with a decrease in PONV, as well as the improved continuation of pain treatment with fentanyl-based IVPCA, similar to IVPCA with morphine. However, it is necessary to monitor the side effects of this treatment.

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Published

2020-06-22

How to Cite

Hirata, I., Iwamoto, M., Matsui, H., Yoshinuma, H., & Funakoshi, R. (2020). Droperidol Reduces Postoperative Nausea and Vomiting and Supports the Continuation of Intravenous Patient-Controlled Analgesia with Fentanyl. Journal of Pharmacy & Pharmaceutical Sciences, 23(1), 220-230. https://doi.org/10.18433/jpps30902

Issue

Section

Clinical Pharmacology and Therapeutics