Recent Advances in Elastin-Based Biomaterial

Authors

  • María Luisa Del Prado Audelo Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico. Escuela de Ingeniería y Ciencias, Departamento de Bioingeniería, Tecnológico de Monterrey, Campus Ciudad de México, Ciudad de México, 14380, Mexico
  • Néstor Mendoza-Muñoz Facultad de Ciencias Químicas, Universidad de Colima, Colima, 28400, Mexico.
  • Lidia Escutia-Guadarrama Departamento de Física, Facultad de Ciencias, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico.
  • David Giraldo-Gomez Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico. Unidad de Microscopía, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico.
  • Maykel González-Torres CONACyT-Laboratorio de Biotecnología, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de México, 14389, Mexico.
  • Benjamín Florán Departamento de Fisiología, Biofísica & Neurociencias, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, 07360, Mexico.
  • Hernán Cortés Laboratorio de Medicina Genómica, Departamento de Genómica, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de México, 14389, Mexico.
  • Gerardo Leyva-Gomez Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico.

DOI:

https://doi.org/10.18433/jpps31254

Abstract

Elastin is one of the main components of the extracellular matrix; it provides resistance and elasticity to a variety of tissues and organs of the human body, besides participating in cellular signaling. On the other hand, elastin-derived peptides are synthetic biopolymers with a similar conformation and structure to elastin, but these possess the advantage of solubility in aqueous mediums. Due to their biological activities and physicochemical properties, elastin and related peptides may be applied as biomaterials to develop diverse biomedical devices, including scaffolds, hydrogels, and drug delivery systems for tissue engineering. Likewise, the combination of elastin with natural or synthetic polymers has demonstrated to improve the mechanical properties of biomedical products and drug delivery systems. Here we comprehensively describe the physicochemical properties and physiological functions of elastin. Moreover, we offer an overview of the use of elastin and its derivative polymers as biomaterials to develop scaffolds and hydrogels for tissue engineering. Finally, we discuss some perspectives on the employment of these biopolymers to fabricate new biomedical products.

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Published

2020-08-17

How to Cite

Del Prado Audelo, M. L., Mendoza-Muñoz, N. ., Escutia-Guadarrama, L., Giraldo-Gomez, D., González-Torres, M. ., Florán, B., Cortés, H. ., & Leyva-Gomez, G. (2020). Recent Advances in Elastin-Based Biomaterial. Journal of Pharmacy & Pharmaceutical Sciences, 23(1), 314-332. https://doi.org/10.18433/jpps31254

Issue

Section

Review Articles