Dual-Light Photodynamic Therapy Effectively Eliminates Streptococcus Oralis Biofilms

Dual-light therapy, Photodynamic therapy, Streptococcus oralis, soft-tissue infections, alternative antimicrobial therapy,

Authors

  • Jessica Hentilä Department of Oral and Maxillofacial Surgery, University of Helsinki and Helsinki University Hospital, Finland
  • Noora Laakamaa Department of Oral and Maxillofacial Surgery, University of Helsinki and Helsinki University Hospital, Finland
  • Timo Sorsa Department of Oral and Maxillofacial Surgery, University of Helsinki and Helsinki University Hospital, Finland and Department of Oral Medicine, Karolinska Institute, Huddinge, Sweden
  • Jukka Meurman Department of Oral and Maxillofacial Surgery, University of Helsinki and Helsinki University Hospital, Finland
  • Hanna Välimaa Department of Oral and Maxillofacial Surgery and Department of Virology, University of Helsinki and Helsinki Hospital, Finland
  • Sakari Nikinmaa Department of Neuroscience and Biomedical Engineering, Aalto University, Finland
  • Esko Kankuri Department of Neuroscience and Biomedical Engineering, Aalto University, Finland
  • Tuomas Tauriainen Heart and Lung Center, Meilahti Hospital, Helsinki, Finland
  • Tommi Pätilä Department of Congenital Heart Surgery and Organ Transplantation, New Children's Hospital, University of Helsinki, Finland

DOI:

https://doi.org/10.18433/jpps32084

Abstract

Purpose: During cancer treatment, oral mucositis due to radiotherapy or chemotherapy often leads to disruption of the oral mucosa, enabling microbes to invade bloodstream. Viridans streptococcal species are part of the healthy oral microbiota but can be frequently isolated from the blood of neutropenic patients.  We have previously shown the antibacterial efficacy of dual-light, the combination of antibacterial blue light (aBL) and indocyanine green photodynamic therapy (aPDT). Methods: Here, we investigated the dual-light antibacterial action against four-day Streptococcus oralis biofilm. In addition, while keeping the total radiant exposure constant at 100J/cm2, we investigated the effect of changing the different relative light energies of aBL and aPDT to the antibacterial potential. Results: The dual-light had a significant antibacterial effect in all the tested combinations. Conclusion: Dual-light can be used as an effective disinfectant against S. oralis biofilm.

 

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Author Biographies

Jessica Hentilä, Department of Oral and Maxillofacial Surgery, University of Helsinki and Helsinki University Hospital, Finland

Equal contribution*

Noora Laakamaa, Department of Oral and Maxillofacial Surgery, University of Helsinki and Helsinki University Hospital, Finland

Equal contribution*

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Published

2021-09-22

How to Cite

Hentilä, J. ., Laakamaa, N., Sorsa, T., Meurman, J., Välimaa, H., Nikinmaa, S., Kankuri, E., Tauriainen, T., & Pätilä, T. (2021). Dual-Light Photodynamic Therapy Effectively Eliminates Streptococcus Oralis Biofilms: Dual-light therapy, Photodynamic therapy, Streptococcus oralis, soft-tissue infections, alternative antimicrobial therapy, . Journal of Pharmacy & Pharmaceutical Sciences, 24, 484–487. https://doi.org/10.18433/jpps32084

Issue

Section

Pharmaceutical Sciences; Original Research Articles