Periostin: A Potential Biomarker and Therapeutic Target in Pulmonary Diseases

Authors

  • Nafaa Alzobaidi Department of Pharmacology, Hamdard Institute of Medical Sciences and Research, New Delhi https://orcid.org/0000-0003-0524-9107
  • Sana Rehman Department of Pharmacology, Hamdard Institute of Medical Sciences and Research (HIMSR), Jamia Hamdard University, New Delhi, India
  • Maaz Naqvi Department of Pharmacology, Hamdard Institute of Medical Sciences and Research, New Delhi
  • Kavita Gulati Department of Pharmacology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.
  • Arunabha Ray 1Department of Pharmacology, Hamdard Institute of Medical Sciences and Research (HIMSR), Jamia Hamdard University, New Delhi, India

DOI:

https://doi.org/10.18433/jpps32306

Abstract

Periostin is a matricellular, nonstructural protein belonging to the fasciclin family and is encoded by the POSTN gene in humans. Periostin plays an important role in maintaining a normal tissue matrix in the lungs. Despite the vital role as a structural mediator in tissue growth and repair, periostin is involved in the pathogenic mechanism during tissue remodeling and fibrosis. Periostin is a chemoattractant mediator, promotes eosinophil recruitment and adhesion on the airways sub-epithelial membrane of asthmatic patients. POSTN gene was identified as one of the highly expressed genes induced by interleukins IL-13, IL-5 and IL-4 - the key cytokines of Th2 immune responses in the bronchial tissues of asthmatic patients. This review highlights the potential role of periostin as a validated biomarker in respiratory disease progression and its candidacy to predict the response to treatments targeting Th-2 cytokines in bronchial asthma. In addition, its potential role in COPD, IPF, lung cancer and lung infection, is also speculated.

 

Keywords

Periostin, Asthma, Pneumonia, COPD, Idiopathic pulmonary fibrosis, Biomarker 

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Published

2022-04-02

How to Cite

Alzobaidi, N., Rehman, S. ., Naqvi, M. ., Gulati, K. ., & Ray, A. (2022). Periostin: A Potential Biomarker and Therapeutic Target in Pulmonary Diseases. Journal of Pharmacy & Pharmaceutical Sciences, 25, 137–148. https://doi.org/10.18433/jpps32306

Issue

Vol. 25 (2022): Pages 1-

Section

Review Articles

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