Intranasal Drug Delivery: How, Why and What for?

  • Anaísa Pires Faculty of Pharmacy, University of Coimbra
  • Ana Fortuna Faculty of Pharmacy, University of Coimbra
  • Gilberto Alves Faculty of Health Sciences, University of Beira Interior
  • Amílcar Falcão Faculty of Pharmacy; University of Coimbra

Abstract

Over the last decade the interest in intranasal delivery as a non-invasive route for drug administration has been exponentially increased. Since the nasal mucosa offers numerous benefits as a target issue for drug delivery, a wide variety of therapeutic compounds may be administered intranasally for topic, systemic and central nervous system action. The present paper reviews the relevant aspects of nasal anatomy, physiology and histology, and refers to the biological, physicochemical and pharmaceutical factors that must be considered during the process of discovery and development of nasal drugs as well as in their incorporation in appropriate nasal pharmaceutical formulations.

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Author Biographies

Anaísa Pires, Faculty of Pharmacy, University of Coimbra
Pharmacology Department & Centre for Neurosciences and Cell Biology (CNC)
Ana Fortuna, Faculty of Pharmacy, University of Coimbra
Pharmacology Department & Centre for Neurosciences and Cell Biology (CNC)
Gilberto Alves, Faculty of Health Sciences, University of Beira Interior
Health Sciences Research Centre (CICS)
Amílcar Falcão, Faculty of Pharmacy; University of Coimbra
Pharmacology Department & Centre of for Neurosciences and Cell Biology (CNC)
Published
2009-10-12
How to Cite
Pires, A., Fortuna, A., Alves, G., & Falcão, A. (2009). Intranasal Drug Delivery: How, Why and What for?. Journal of Pharmacy & Pharmaceutical Sciences, 12(3), 288-311. https://doi.org/10.18433/J3NC79
Section
Review Articles