Strategies to Prolong the Intravaginal Residence Time of Drug Delivery Systems

  • Esra Baloglu Ege University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Bornova, Izmir, 35100, Turkey.
  • Andreas Bernkop-Schnürch Institute of Pharmacy, University of Innsbruck, Innrain 52, 6020 Innsbruck.
  • Sinem Yaprak Karavana Ege University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Bornova, Izmir, 35100, Turkey.
  • Zeynep Ay Senyigit Ege University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Bornova, Izmir, 35100, Turkey.

Abstract

The vagina has been studied as a favorable site for local and systemic delivery of drugs for female-related conditions. There are a large number of vaginal medications on the market and most of them require frequent application due to their short vaginal residence time. A prolonged vaginal residence time of formulations is therefore a key parameter for improved therapeutic efficacy. Promising approaches to prolong the residence time base on mucoadhesion, in- situ sol-gel transition and mechanical fixation. Mucoadhesive drug delivery systems can be tailored to adhere to the vaginal tissue. In-situ gelling systems offer the advantage of increased viscosity in vaginal cavity and consequently reduce outflow from the vagina. Mechanical fixation needs specially shaped drug delivery systems and reduce the frequency of administration significantly. Within this review an overview on these different strategies and systems is provided. Furthermore, the techniques to evaluate the potential of these systems for prolonged vaginal residence time are described.

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Author Biographies

Esra Baloglu, Ege University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Bornova, Izmir, 35100, Turkey.
Department of Pharmaceutical Technology
Andreas Bernkop-Schnürch, Institute of Pharmacy, University of Innsbruck, Innrain 52, 6020 Innsbruck.
Department of Pharmaceutical Technology
Sinem Yaprak Karavana, Ege University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Bornova, Izmir, 35100, Turkey.
Department of Pharmaceutical Technology
Zeynep Ay Senyigit, Ege University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Bornova, Izmir, 35100, Turkey.
Department of Pharmaceutical Technology
Published
2009-10-13
How to Cite
Baloglu, E., Bernkop-Schnürch, A., Karavana, S. Y., & Ay Senyigit, Z. (2009). Strategies to Prolong the Intravaginal Residence Time of Drug Delivery Systems. Journal of Pharmacy & Pharmaceutical Sciences, 12(3), 312-336. https://doi.org/10.18433/J3HP41
Section
Review Articles