Safety Assessment of Potentially Inappropriate Medications Use in Older People and the Factors Associated with Hospital Admission

Authors

  • Fabiana Rossi Varallo School of Pharmaceutical Sciences of the Universidade Estadual Paulista Júlio de Mesquita Filho, Araraquara (SP)
  • Helaine Carneiro Capucho Risk Management of Clinical Hospital of Ribeirão Preto, University of São Paulo-Ribeirão Preto
  • Cleópatra Silva Planeta School of Pharmaceutical Sciences of the Universidade Estadual Paulista Júlio de Mesquita Filho, Araraquara (SP)
  • Patrícia de Carvalho Mastroianni School of Pharmaceutical Sciences of the Universidade Estadual Paulista Júlio de Mesquita Filho, Araraquara (SP)

DOI:

https://doi.org/10.18433/J3P01J

Abstract

Purpose: Potentially Inappropriate Medications (PIM) use in elderly people may be responsible for the development of Adverse Drug Reaction (ADR) which, when severe, leads to hospital admissions. Objectives: to estimate the prevalence of elderly who had used PIM before being admitted to hospital admission and to identify the risk factors and the hospitalizations related to ADR arising from PIM. Methods: A descriptive and cross-sectional study was performed in the internal medicine ward of a teaching hospital (Brazil), in 2008. With the aid of a validated form, patients aged ≥ 60 years, with length of hospital stay ≥ 24 hours, were interviewed about drugs taken prior to the hospital admission and the complaints/reasons for hospitalization. Results: 19.1% (59/308) of older patients had taken PIM before hospital admission and in 4.9%; there were a causal relation between the PIM taken and the complaint reported. PIM responsible for admissions were: amiodarone, amitriptyline, cimetidine, clonidine, diazepam, digoxin, estrogen, fluoxetine, lorazepam, short-acting nifedipine and propranolol. 47.0% of the clinical manifestations of PIM-related ADR were: dizziness, fatigue, digoxin toxicity and erythema. Only polypharmacy was detected as a risk factor for the occurrence of ADR of PIM (p = 0.02). Conclusion: PIM use in elderly people is not a risk factor for ADR-related hospital admission. Probably, severe ADR, which lead to hospitalizations of older people, can be explained by idiosyncratic response or the predisposition of these patients to develop adverse drug events, whether or not drugs are classed as PIM. Key-words: potentially inappropriate medication (PIM), older people, adverse drug reaction (ADR), hospital admission, pharmacovigilance

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Author Biographies

Fabiana Rossi Varallo, School of Pharmaceutical Sciences of the Universidade Estadual Paulista Júlio de Mesquita Filho, Araraquara (SP)

Department of Drugs and Medicines

Cleópatra Silva Planeta, School of Pharmaceutical Sciences of the Universidade Estadual Paulista Júlio de Mesquita Filho, Araraquara (SP)

Department of Natural Active Principles and Toxicology

Patrícia de Carvalho Mastroianni, School of Pharmaceutical Sciences of the Universidade Estadual Paulista Júlio de Mesquita Filho, Araraquara (SP)

Department of Drugs and Medicines

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Published

2011-07-02

How to Cite

Varallo, F. R., Capucho, H. C., Planeta, C. S., & Mastroianni, P. de C. (2011). Safety Assessment of Potentially Inappropriate Medications Use in Older People and the Factors Associated with Hospital Admission. Journal of Pharmacy &Amp; Pharmaceutical Sciences, 14(2), 283–290. https://doi.org/10.18433/J3P01J

Issue

Section

Pharmaceutical Sciences; Review Articles