TY - JOUR AU - Shahbazi, Foroud AU - Dashti-Khavidaki, Simin AU - Khalili, Hossein AU - Lessan-Pezeshki, Mahboob PY - 2012/01/20 Y2 - 2024/03/28 TI - Potential Renoprotective Effects of Silymarin Against Nephrotoxic Drugs: A Review of Literature JF - Journal of Pharmacy & Pharmaceutical Sciences JA - J Pharm Pharm Sci VL - 15 IS - 1 SE - Review Articles DO - 10.18433/J3F88S UR - https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/12374 SP - 112-123 AB - Drug-induced nephrotoxicity (DIN) accounts for up to sixty percent of hospital acquired acute kidney injury. Several efforts have been made to reduce drug-induced renal damage; however, DIN remains a matter of concern, with substantial impact on patients and the health system. Silymarin is a drug that has been used for many years in alternate and modern medicine for treating hepatic diseases. Its antioxidant, anti-inflammatory and anti-apoptotic effects make it an interesting herbal medicine, and these properties have implicated this compound as a potential renoprotective agent. Based on the findings from animal studies, this review concluded that silymarin might exert significant protective or ameliorative effects against drug-induced kidney disease, especially against cisplatin-induced renal damage. Whether the protective administration of silymarin could be an effective clinical pharmacological strategy to prevent DIN is a question that remains to be answered in clinical trials.This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page. ER -