TY - JOUR AU - Alsaab, Hashem AU - Bonam, Sindhu Prabha AU - Bahl, Dherya AU - Chowdhury, Pallabita AU - Alexander, Kenneth AU - Boddu, Sai HS. PY - 2016/07/12 Y2 - 2024/03/29 TI - Organogels in Drug Delivery: A Special Emphasis on Pluronic Lecithin Organogels JF - Journal of Pharmacy & Pharmaceutical Sciences JA - J Pharm Pharm Sci VL - 19 IS - 2 SE - Review Articles DO - 10.18433/J3V89W UR - https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/27641 SP - 252-273 AB - <p>Organogels have emerged as an alternative carrier for small and macromolecules via transdermal, oral, rectal and ophthalmic routes. Pluronic lecithin organogels (PLO gels) are lecithin-based organogels widely used in compounding pharmacies as a vehicle for enhancing the transdermal permeability of many therapeutic drugs. However, the scientific and systematic evidence in support of how well PLO gels help in transdermal delivery is scanty. Recently, some clinical studies have reported nearly complete lack of bioavailability of certain topically administered drugs from PLO gels. The present review aims at summarizing gels and organogels, with a focus on the use of PLO gels in transdermal drug delivery. A special emphasis is placed on controversies looming over the use of PLO gels as a delivery platform for drugs via transdermal route.</p><p> </p><p>This article is open to <strong>POST-PUBLICATION REVIEW</strong>. Registered readers (see “For Readers”) may <strong>comment</strong> by clicking on ABSTRACT on the issue’s contents page.</p> ER -