TY - JOUR AU - Lawati, Hanan Al AU - Jamali, Fakhreddin PY - 2016/08/17 Y2 - 2024/03/28 TI - Onset of Action and Efficacy of Ibuprofen Liquigel as Compared to Solid Tablets: A Systematic Review and Meta-Analysis JF - Journal of Pharmacy & Pharmaceutical Sciences JA - J Pharm Pharm Sci VL - 19 IS - 3 SE - Systematic Review and Meta-Analysis DO - 10.18433/J3B897 UR - https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/28210 SP - 301-311 AB - <p><strong>Purpose. </strong>Ibuprofen liquigel has been believed to provide faster analgesic effect. However, comparative studies evaluating the efficacy of liquigel versus regular tablets are not available. Hence, we carried out a systematic review and a meta-analysis to compare the onset of action and efficacy of over-the-counter doses of ibuprofen liquigel (IBU<sub>LG</sub>) vs ibuprofen tablets (IBU<sub>T</sub>).  <strong>Methods.</strong> Published clinical trials of IBU<sub>LG</sub> and IBU<sub>T</sub> were identified through a systematic search of various data bases up to October, 2015. <strong>Results</strong>. In total 18 eligible studies on IBU<sub>T</sub> and 4 on IBU<sub>LG </sub>were found.  There was no significant difference in the median time to the first perceptible pain relief or the proportion of patients with more than 50% pain relief between the two products. However, IBU<sub>LG</sub> yielded significantly greater odd ratios in meaningful pain relief at 60, 90 and 120 min, but not at 30 min, as compared with IBU<sub>T</sub>.  <strong>Conclusion.</strong> The available evidence, although not overwhelming, suggest a faster onset of analgesia for liquigel as compared with tablets.</p><p> </p><p>This article is open to <strong>POST-PUBLICATION REVIEW</strong>. Registered readers (see “For Readers”) may <strong>comment</strong> by clicking on ABSTRACT on the issue’s contents page.</p> ER -