An Old Drug for a New Application: Potential Benefits of Sildenafil in Wound Healing

  • Shadi Farsaie Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  • Hossein Khalili
  • Iman Karimzadeh Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  • Simin Dashti-Khavidaki Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Abstract

Purpose: Several studies have evaluated the effects of sildenafil on the tissue repair and wound healing. In the present review, the impact of sildenafil on the wound healing in all available clinical and non-clinical (experimental) studies has been discussed. Methods: A literature search was performed using PubMed, Scopus, Medline, Embase, Cochrane central register of controlled trials and Cochrane database systematic reviews. Related articles indexed in Google Scholar were also included. Key words used as search terms were ‘phosphodiesterase inhibitor’, ‘sildenafil’, ‘skin’, ‘cutaneous’, ‘skin lesion’, ‘skin damage’, ‘wound’, and ‘wound healing’. No time limitation was considered in this review. Results: A total of 15 animal studies, 7 case reports, and 2 small clinical studies have reported the effects of sildenafil on the wound healing. The effects included skin flaps and grafts, anastomosis, systemic sclerosis and Raynaud's disease. Conclusions: The available data support the beneficial effects of sildenafil in improvement of tissue healing in various conditions. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

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Published
2012-08-14
How to Cite
Farsaie, S., Khalili, H., Karimzadeh, I., & Dashti-Khavidaki, S. (2012). An Old Drug for a New Application: Potential Benefits of Sildenafil in Wound Healing. Journal of Pharmacy & Pharmaceutical Sciences, 15(4), 483-498. https://doi.org/10.18433/J3TC7V
Section
Review Articles