Correlation of Lipid Peroxidation and Glutathione Levels with severity of Systemic Lupus Erythematosus: a Pilot study from Single Center

Karunrat Tewthanom

Silpakorn University



Systemic Lupus Erythematosus (SLE) is a multifactoral chronic autoimmune disease with unidentified etiology. Imbalance of oxidative status is one possible cause of active disease. Plasma malondialdehyde (MDA) and plasma glutathione (GSH) level have been used as a determinate of oxidative status. Limited data has examined these 2 parameters by severity of SLE. Therefore, the purpose of this study was to determine if an association between plasma MDA and plasma GSH level with the severity of SLE . Twenty healthy volunteers (3 Men, 17 women) and 44 SLE patients (2 Men and 42 Women) participated in this study. SLE participants were classified by the severity of disease (mild, moderate or severe). The plasma MDA and plasma Glutathione level were measured. The correlation of plasma MDA and plasma Glutathione levels with the severity of SLE disease were determined. No correlation of plasma MDA level among the 4 groups with different severity of SLE (Control, mild, moderate, and severe of SLE patients) was observed at p <0.005 level. The plasma GSH level was significantly different among 3 SLE groups as compared to the control group (p=0.001). In addition, a significant correlation between plasma GSH and severity of SLE was observed. (pearson correlation = -0.479, p=0.001). The model that predicted the plasma GSH level based on the severity was as follows: GSH level (mM) = (-132.25) (Group severity) +655.578 (p= 0.001) . There was significant correlation between plasma GSH and severity of SLE. Further research is needed to determine if supplemental GSH precursors could reduce the severity of SLE. Other factors that may affect plasma GSH and plasma MDA should be included in future data analysis. In addition, a larger sample size will be useful to evaluate the impact of these factors on plasma GSH and plasma MDA.

Key words: lupus erythematosus; lipid peroxidation; glutathione levels

J Pharm Pharm Sci, 11 (3): 30-34, 2008

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