Pharmacologic Activities¬ of 3’-Hydroxypterostilbene: Cytotoxic, Anti-Oxidant, Anti-Adipogenic, Anti-Inflammatory, Histone Deacetylase and Sirtuin 1 Inhibitory Activity

Authors

  • Jody K Takemoto Department of Pharmaceutical Sciences, Ben and Maytee Fisch College of Pharmacy, The University of Texas at Tyler, Tyler, Texas. Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, Washington.
  • Connie M. Remsberg Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, Washington. Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, Washington.
  • Neal M. Davies Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, Washington. College of Pharmacy, Faculty of Health Sciences, University of Manitoba, Winnipeg R3E 0T4, Manitoba, Canada.

DOI:

https://doi.org/10.18433/J33W4C

Abstract

Purpose: Delineate the selected pharmacodynamics of a naturally occurring stilbene 3’-Hydroxypterostilbene. Objective: Characterize for the first time the pharmacodynamics bioactivity in several in-vitro assays with relevant roles in heart disease, inflammation, cancer, and diabetes etiology and pathophysiology. Methods: 3’-Hydroxypterostilbene was studied in in-vitro assays to identify possible bioactivity. Results: 3’-Hydroxypterostilbene demonstrated anti-oxidant, anti-inflammatory, cytotoxic, anti-adipogenic, histone deacetylase, and sirtuin-1 inhibitory activity. Conclusions: The importance of understanding individual stilbene pharmacologic activities were delineated.  Small changes in chemical structure of stilbene compounds result in significant pharmacodynamic differences.

 

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Author Biography

Jody K Takemoto, Department of Pharmaceutical Sciences, Ben and Maytee Fisch College of Pharmacy, The University of Texas at Tyler, Tyler, Texas. Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, Washington.

   

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Published

2015-11-10

How to Cite

Takemoto, J. K., Remsberg, C. M., & Davies, N. M. (2015). Pharmacologic Activities¬ of 3’-Hydroxypterostilbene: Cytotoxic, Anti-Oxidant, Anti-Adipogenic, Anti-Inflammatory, Histone Deacetylase and Sirtuin 1 Inhibitory Activity. Journal of Pharmacy & Pharmaceutical Sciences, 18(4), 713–727. https://doi.org/10.18433/J33W4C

Issue

Vol. 18 No. 4 (2015)

Section

CLOSED. Special Issue - Chief Guest Editor: Basil D Roufogalis; Co-Guest Editors: Emanuel Strehler & Srinivas Nammi

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