Microneedles as Enhancer of Drug Absorption Through the Skin and Applications in Medicine and Cosmetology

Pablo Serrano-Castañeda1, Jose Juan Escobar-Chavez2, Isabel Marlen Rodriguez-cruz3, Luz Maria Melgoza4, Jessica Martinez-Hernandez2

1Doctorado en Ciencias Biológicas y de la Salud de la Universidad Autónoma Metropolitana. México. Facultad de Estudios Superiores Cuautitlán-Universidad Nacional Autónoma de México. Unidad de Investigación Multidisciplinaria. Estado de México, México.
2Facultad de Estudios Superiores Cuautitlán-Universidad Nacional Autónoma de México. Unidad de Investigación Multidisciplinaria. Estado de México, México.
3Hospital Regional de Alta Especialidad de Zumpango. Unidad de Enseñanza e Investigación. Zumpango Estado de México, México.
4Doctorado en Ciencias Biológicas y de la Salud de la Universidad Autónoma Metropolitana. México.

Abstract


The microneedles technology has found applications in many health-related fields. For example, their application in drugs and vaccines delivery as well, as the determination of biomarkers, has been reported. They also have a place in the dermatology and cosmetic areas such as the treatment of wounds from burns, scars, acne, depigmentation, and alopecia will be shown. Microneedles are used in therapeutic applications and are manufactured using materials such as metal (steel, titanium, nickel), polymer (oly-glycolic acid (PGA), poly-lactide-co-glycolide acid (PLGA), poly-L-lactic acid (PLA), chitosan), glass, silicon, ceramic, carbohydrates (trehalose, sucrose, mannitol). Examples of application of microneedles and their advantages and disadvantages are discussed.

 

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J Pharm Pharm Sci, 21 (0): 73-93, 2018

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DOI: http://dx.doi.org/10.18433/jpps29610