Vol. 21 (2018): Pages 1-142

Published: 2018-03-30

Pharmaceutical Sciences; Original Research Articles

In Endothelial Cells, the Activation or Stimulation of Soluble Guanylyl Cyclase Induces the Nitric Oxide Production by a Mechanism Dependent of Nitric Oxide Synthase Activation

Ariane Migliato Martinelli, Carla Nascimento dos Santos Rodrigues, Thiago Francisco de Moraes, Gerson Jhonatan Rodrigues

38-45
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Targeted Delivery of Amantadine-loaded Methacrylate Nanosphere-ligands for the Potential Treatment of Amyotrophic Lateral Sclerosis

Zamanzima Mazibuko, Sunaina Indermun, Mershen Govender, Pradeep Kumar, Lisa C du Toit, Yahya E Choonara, Girish Modi, Dinesh Naidoo, Viness Pillay

94-109
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Considerations and Pitfalls in Selecting the Drug Vehicles for Evaluation of New Drug Candidates: Focus on in vivo Pharmaco-Toxicological Assays Based on the Rotarod Performance Test

Mariana Matias, Samuel Silvestre, Amílcar Falcão, Gilberto Alves

110-118
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Inhibition of BMP4 and Alpha Smooth Muscle Actin Expression in LX-2 Hepatic Stellate Cells by BMP4-siRNA Lipid Based Nanoparticle

Refaat Omar, Jiaqi Yang, Samaa Alrushaid, Frank J. Burczynski, Gerald Y. Minuk, Yuewen Gong

119-134
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Effect of Cytochrome P450 (CYP) 2D6 Genetic Polymorphism on the Inhibitory Action of Antidepressants on CYP2D6-Mediated Dopamine Formation from p-Tyramine

Toshiro Niwa, Mayumi Yanai, Maya Matsumoto, Marina Shizuku

135-142
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Clinical Pharmacology and Therapeutics

Diclofenac--Acetaminophen Combination Induced Acute Kidney Injury In Postoperative Pain Relief

Yan Zhu, Ping Xu, Qing Wang, Jian-quan Luo, Yi-wen Xiao, Yi-yi Li, Yan-gang Zhou, Andrew Cave, Hoan Linh Banh

19-26
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Analysis of patients with hypomagnesemia using the Japanese Adverse Drug Event Report database (JADER)

Hiroyuki Tanaka, Yuka Yoshiba, Tomoko Watanabe, Mitsutoshi Satoh, Toshihiro Ishii

46-53
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Evaluation of the Benefits of De-Escalation for Patients with Sepsis in the Emergency Intensive Care Unit

Takahiro Niimura, Yoshito Zamami, Toru Imai, Kanako Nagao, Masafumi Kayano, Hidenori Sagara, Mitsuhiro Goda, Naoto Okada, Masayuki Chuma, Kenshi Takechi, Masaki Imanishi, Toshihiro Koyama, Tadashi Koga, Hironori Nakura, Toshiaki Sendo, Keisuke Ishizawa

54-59
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Review Articles

The Remarkable Cationic Peptides: A Boon to Pharmaceutical Sciences?

Ruchi Omar, Arpita Yadav

60-72
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Microneedles as Enhancer of Drug Absorption Through the Skin and Applications in Medicine and Cosmetology

Pablo Serrano-Castañeda, Jose Juan Escobar-Chavez, Isabel Marlen Rodriguez-cruz, Luz Maria Melgoza, Jessica Martinez-Hernandez

73-93
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Systematic Review and Meta-Analysis

Association Between HLA genotypes and Oxcarbazepine-induced Cutaneous Adverse Drug Reactions: A Systematic Review and Meta-Analysis

Wimonchat Tangamornsuksan, Norman Scholfield, Manupat Lohitnavy

1-18
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Reports

A Survey of the Regulatory Requirements for BCS-Based Biowaivers for Solid Oral Dosage Forms by Participating Regulators and Organisations of the International Generic Drug Regulators Programme

Joy Elizabeth van Oudtshoorn, Alfredo García-Arieta, Gustavo Mendes Lima Santos, Christopher Crane, Clare Rodrigues, Craig Simon, Ji Myoung Kim, Sang Aeh Park, Yusuke Okada, Ryosuke Kuribayashi, Chantal Pfäffli, Arno Nolting, Iván Omar Calderón Lojero, Zulema Rodríguez Martínez, Wen-Yi Hung, April C. Braddy, Nancy Arciniegas Leal, Diego Gutierrez Triana, Mitch Clarke, Peter Bachmann

27-37
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